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학술발표회초록보기

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  • 02월 19일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제119회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of TLR7 Agonists Conjugated Iron Oxide Nanoparticles to Elicit Robust Cytotoxic T Cell Responses via DC Activation

등록일
2017년 2월 16일 13시 26분 21초
접수번호
4394
발표코드
BIO.P-320 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 21일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
홍성유*, 김우겸1
UNIST 나노생명화학공학부, Korea
1UNIST 화학공학과, Korea
Recognitionis of pathogen-associated molecular patterns (PAMPs) is the first steps in immune therapy. Especially, Toll-like receptors (TLRs) in dendritic cell (DC) are representative pattern recognition receptors, which is critical for coordinating innate and adaptive immune responses. Imidazoquinolines, known as artificial compounds commerically available as TLR7 agonists, were attacked in aspect of efficiency because of their small size and short half-life in the bloodstream. Here, we synthesized covalent incorporation of imidazoquinoline moieties onto the surface of iron oxide nanoparticles to enhance their chemical stability, cellular uptake efficiency, and adjuvanticity. We utilized copper-catalyzed click reaction (CuAAC) to make novel conjugation between adjuvant and nanoparticles and these synthetic adjuvant-nanocomplexes showed powerful DC activation with lower nanomolar doses. Furthermore we checked unusually strong cytotoxic T lymphocyte responses, by the addition of ovalbumin, because conjugation to macromolecules could induce multivalency effect and efficient transport to endosomal TLR7.

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