초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 02월 19일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제119회 대한화학회 학술발표회, 총회 및 기기전시회 안내 New bicyclic brominated furanones: Potent autoinducer-2 quorum sensing inhibitors against periodontal biofilm formation

2017년 2월 16일 14시 26분 28초
ORGN.P-398 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 20일 (목요일) 11:00~12:30
저자 및
박지수, 김병문*
서울대학교 화학부, Korea

Bacterial behaviors, including virulence factor expression, bioluminescence, and biofilm formation, are effectively regulated through quorum sensing, a mechanism of intra- and interspecies communication in response to changes in cell density through recognition of the threshold reached by autoinducers. Among these bacterial behaviors, formation of a biofilm can be the basis of the development of chronic inflammatory diseases. Periodontitis, a chronic inflammatory disease affecting the periodontium, is caused by subgingival biofilms related to periodontopathogens. In particular, Fusobacterium nucleatum is known as a major co-aggregation bridge organism that connects early commensal colonizers and late pathogenic colonizers in periodontal biofilms. According to a previous study, the intergeneric quorum sensing signal molecule autoinducer-2 (AI-2) of F. nucleatum plays a key role in intra- and interspecies interactions of periodontopathogens, and may be a good target for periodontal biofilm inhibition. Recently, brominated furanones produced by the macroalga Delisea pulchra were shown to inhibit biofilm formation, and have been investigated toward the goal of increasing the inhibition effect. In this study, to improve the antagonistic activity and better understand structure-activity relationship, we describe the synthesis of new brominated furanone analogs, i.e., 3-(dibromomethylene)isobenzofuran-1(3H)-one derivatives, and demonstrate their inhibitory activities against biofilm formation by periodontopathogens.