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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 02월 19일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제119회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Light-triggered Drug Release and Photothermal Therapy using Gold Nanorods

등록일
2017년 3월 17일 17시 26분 49초
접수번호
5206
발표코드
MAT.P-501 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 21일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
양수정, 이정민, 박명환*
삼육대학교 화학과, Korea
Chemotherapy is a major therapeutic approach for the treatment of cancers, but nonspecific delivery of drugs leads to normal tissues toxicities. Photothermal therapy using near-infrared(NIR) has attracted in recent years because harmless NIR can penetrate tissues more deeply. However most photothermal agents can not provide an efficient heat transfer to cancer cells. Combining treatments with photothermal and chemotherapy is desirable to improve these problems and enhance the therapeutic efficacy. Here, we designed a NIR light-sensitive new biomaterial to achieve a synergized photothermal-chemotherapy of cancers. The camptothecin functionalized gold nonorods were fabricated through one-step place exchange reactions from cetyltrimethylammonium bromide(CTAB) gold nanorods. These materials can strongly absorb NIR light(808nm) and convert it into cytotoxic localized-heat, which accelerates release of drugs at elevated temperature. This combination of photothermal and chemotherapy has been proved to be more effective than respective monotherapies. The structural formation was characterized using ultraviolet-visible(UV) spectroscopy, Fourier transform infrared(FT-IR) spectroscopy and dynamic light scattering(DLS) spectroscopy. The release behavior of drugs induced by exposing NIR was analyzed by fluorescence spectroscopy.

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