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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Dihydrophosphaisocoumarins through a Palladium-Catalyzed Oxidative Cyclization of Arylphosphonic Acid Monoethyl Esters with 1,3-Dienes

등록일
2017년 8월 3일 16시 05분 16초
접수번호
0196
발표코드
ORGN.P-244 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Kyusik Um, hyunseok kim1, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea
1Kangwon National University, Korea

Organophosphorus compounds are an omnipresent structural motif found in living organisms and biologically active compounds, and their facile synthesis is important in the preparation of synthetic intermediates, agrochemicals, and pharmaceuticals. Additionally, these compounds have continuously attracted great interest due to their role as bioisosteres of carbonyl and carboxylate groups. Accordingly, much effort has been devoted not only to construct skeletons of phosphorus compounds but also to introduce new functional groups onto these compounds. However, in contrast their acyclic analogs, the synthesis and application of phosphaheterocyclic compounds have been rarely investigated. We developed an efficient synthetic method for the selective preparation of dihydro-phosphaisocoumarins and their derivatives through a Pd-catalyzed oxidative cyclization reaction of a wide range of arylphosphonic acid monoethyl esters with activated and unactivated 1,3-dienes, including 1-aryl-substituted 1,3-dienes and 1-alkyl-substituted 1,3-dienes, thus opening a new avenue for the synthesis of phosphaheterocyclic compounds.


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