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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Cyclic Sulfoximines from Sulfoximines and 3-Diazoindolin-2-imines

등록일
2017년 8월 3일 16시 05분 57초
접수번호
0197
발표코드
ORGN.P-245 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Gi Hoon Ko, hyunseok kim1, Kyusik Um, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea
1Kangwon National University, Korea

Sulfoximines are significant compounds that are found in pharmaceuticals, bioactive compounds, and agochemicals. Accordingly, the development of novel synthetic methods for sulfoximines and their modifications have become highly attractive. To date, many synthetic methods using these tools have been reported in the literature. These methods have focused mainly on the preparation of linear sulfoximines and their derivatives. However, synthetic approaches for the construction of cyclic sulfoximines have been relatively limited. We developed a novel synthetic method for indolo-1,2-benzothiazines via the Rh-catalyzed cyclization of S-aryl sulfoximines with 3-diazoindolin-2-imines together with the release of molecular nitrogen and p-toluenesulfonamide. The present method involved the N−H/C−H activation of S-aryl sulfoximines. A wide-ranging scope of both S-aryl sulfoximines and 3-diazoindolin-2-imines was demonstrated. This work was supported by the Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation of Korea (NRF-2015H1C1A1035955)


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