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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rhodium-Catalyzed Intramolecular Transannulation of Alkynyl Thiadiazole

등록일
2017년 8월 3일 16시 06분 21초
접수번호
0198
발표코드
ORGN.P-246 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Younghyeon Baek, Da-Hye Jeon, Dongjin Kang1, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea
1Department of Pharmaceutics, Inje University, Korea

Fused thiophenes have been recognized as very important scaffolds in the field of pharmaceutical and functional materials sciences. For this reason, the development of an efficient synthetic method for functionalized fused thiophenes is highly attractive and poses a significant challenge. However, because some of the previously reported synthetic methods demand a strong base, long reaction times, and vigorous reaction conditions, the development of efficient synthetic approaches to overcome these shortcomings has been continuously required. Herein, we developed a method for the synthesis of a wide range of fused thiophenes, including those fused with lactams, lactones, or cyclic ethers, from a rhodium-catalyzed intramolecular transannulation reaction of alkynyl thiadiazoles. This transannulation reaction provides an efficient platform for the construction of a variety of 5,n-fused thiophenes from readily available starting materials together with the release of molecular nitrogen.


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