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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Benzofulvene Derivatives via Rh-Catalyzed Transannulation of Enynyl Triazoles

등록일
2017년 8월 3일 16시 07분 12초
접수번호
0200
발표코드
ORGN.P-248 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Uiseong Yeon, Sang Hoon Han, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea

Benzofulvenes are key privileged scaffolds present in natural products, biologically and pharmacologically active molecules, functional materials, and metallocene catalysts. Due to its significance, it is still of considerable interest and necessity to develop efficient synthetic methods for functionalized benzofulvenes. Recently, N-sulfonyl-1,2,3-triazoles, easily obtained from click reactions, have been used for the preparation of a large number of heterocyclic and carbocyclic compounds through Rh-catalyzed denitrogenative cyclization. On the basis of these results, Rh-catalyzed denitrogenative cyclization of (E)-ethyl 2-(1-alkyl and arylsulfonyl-1H-1,2,3-triazol-4-yl)-3-aryl acrylate generated from (E)-ethyl 2-benzylidenebut-3-ynoates and N-sulfonyl azides in the presence of a copper catalyst was demonstrated for the synthesis of a wide range of functionalized benzofulvenes. Additionally, we have developed straightforward synthetic procedures for three benzofulvenes through tandem Cu-catalyzed [3 + 2] cycloaddition and Rh-catalyzed denitrogenative cyclization from (E)-ethyl 2-benzylidenebut-3-ynoates and N-sulfonyl azides in a one-pot.


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