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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Isothiazoles through Rh-Catalyzed Transannulation of 1,2,3-Thiadiazoles with Nitriles

등록일
2017년 8월 3일 16시 07분 55초
접수번호
0202
발표코드
ORGN.P-250 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Boram Seo, kuhwan jeong, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea

Isothiazoles are valuable structural motifs found in many natural products, pharmaceutical compounds, and functional materials. For this reason, streamlined methods for their synthesis from readily available compounds must be developed. Herein, we developed a synthetic method for obtaining a wide variety of isothiazoles by the Rh-catalyzed transannulation of 1,2,3-thiadiazoles with alkyl, aryl, and heteroaryl nitriles, which proceeds via an α-thiavinyl Rh-carbenoid intermediate. The results suggest that during its reaction with nitriles, the α-thiavinyl carbene acts as an umpolung 1,3-dipole equivalent, in contrast to its behavior during its reaction with alkynes. The developed method was successfully employed to synthesize pentaoligomeric arylene compounds consisting of three benzene and two isothiazole rings.


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