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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of 1,2-Benzothiazines via a Rhodium-Catalyzed Cascade C-H Activation/Cyclization/Elimination Process from Sulfoximines and Pyridotriazoles

등록일
2017년 8월 3일 16시 08분 43초
접수번호
0204
발표코드
ORGN.P-252 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jeong-Yu Son, Gi Uk Han, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea

Sulfoximines are novel privileged scaffolds that have been applied as pharmaceuticals and bioactive compound as well as ligands and chiral auxiliaries in asymmetric syntheses. As a consequence, the development of efficient methods for the synthesis of sulfoximines and their functionalizations is greatly needed. However, despite the significant advances made in the functionalization of sulfoximines, only a few examples of 1,2-benothiazines, which are more attractive pharmacophores as a type of cyclic sulfoximine, have been reported. Herein, we have developed an efficient synthetic method for a wide range of 1,2-benzothiazines bearing pyridyl as well as carbonyl groups by a rhodium-catalyzed domino C−H activation/cyclizetion/elimination of alcohol process starting from S-aryl sulfoximine and pyridotriazole compounds.This work was supported by the Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation of Korea (NRF-2015H1C1A1035955)


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