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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthetic Method of Pyridoisoquinolinones via Cobalt-Catalyzed Carbonylative Cyclization of Pyridinyl Diazoacetates

등록일
2017년 8월 3일 16시 09분 27초
접수번호
0206
발표코드
ORGN.P-254 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Younghyeon Baek, Minhyeon Byeon, Dongjin Kang1, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea
1Department of Pharmaceutics, Inje University, Korea

Transition-metal-catalyzed carbonylation using carbon monoxide is one of the significant methods to prepare a variety of carbonyl compounds. In particular, Pd-catalyzed carbonylative cross-coupling is an important method for the synthesis of a large number of compounds having the carbonyl functional group. However, the carbonylation of metal carbenes is rarely reported due to the limitations of substrate scope and harsh conditions, such as the high pressure of carbon monoxide, high reaction temperature, and stoichiometric processes. Moreover, because the carbonylation of metal carbene furnishes ketenes, which are very important in organic synthesis, the development of streamlined synthetic methods to overcome these shortcomings is still highly attractive and challenging. In conclusion, we have successfully developed a dicobalt octacarbonyl catalyzed carbonylative cyclization of pyridinyl diazoacetates for the synthesis of pyridoisoquinolinones under a carbon monoxide atmosphere. Moreover, a useful synthetic method for a wide range of pyridoisoquinolinones from pyridinyl aryl acetates has been demonstrated through diazotization using TsN3 and DBU followed by Co-catalyzed carbonylation and intramolecular cyclization of ketene with a tethering pyridinyl moiety under a carbon monoxide atmosphere in a semi-one-pot procedure. These transformations are attractive due to the use of an inexpensive and commercially available Co catalyst and an easily accessible starting material and the release of harmless N2 under mild conditions (room temperature).


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