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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Derivatization of Peptoids Using Chan-Lam Reaction

등록일
2017년 8월 9일 18시 15분 07초
접수번호
0269
발표코드
ORGN.P-261 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jihyun Song, Yong-Uk Kwon*
Department of Chemistry and Nanoscience, Ewha Womans University, Korea
Peptides are representative biomolecules that possess various physiological activities in vivo. Thus, they are attractive chemical tools for chemical biology and drug development. However, peptides have unwanted drawbacks including a proteolytic degradation, insufficient cell permeability, etc. To overcome these defects, many different types of peptidomimetics have been developed. Among them, peptoids emerged as valuable molecular tools. They have many advantages such as easy synthesis, tremendous diversity in library construction, resistance to proteolytic degradation and improved cell permeability. Hence, peptoids have attracted great attention to many chemists, pharmacologists, biologists, etc. The N-arylation/O-arylation methodology using Chan-Lam cross coupling reaction is a powerful synthetic tool. Therefore, we have employed Chan-Lam reaction in solid phase synthesis for efficient functionalization of peptoids to maximize their diversity. It was also applied to develop cyclic peptoids as a new macrocyclization method. In this presentation, we will report herein synthetic studies for the interesting derivatization of peptoids using Chan-Lam reaction on solid-phase.

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