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학술발표회초록보기

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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Solid-Phase Total Synthesis of Peptoid-Based Daptomycin Analog

등록일
2017년 8월 9일 18시 20분 57초
접수번호
0270
발표코드
ORGN.P-262 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Hyun-Ju Im, Yong-Uk Kwon*
Department of Chemistry and Nanoscience, Ewha Womans University, Korea
Peptides are interesting molecules that can be used as chemical tools in medicine, biochemical sciences, protein capture and purification, diagnostics, etc. But, there are several unexpected drawbacks such as limited cell permeability, sensitivity to proteases and poor bioavailability. Therefore, various peptidomimetics have been developed to overcome these disadvantages. Among them, peptoids (N-substituted oligoglycines) not only complement these shortcomings but also have several advantages such as improved cell permeability, easy synthesis and high cellular stability. Especially cyclic peptoids may possess higher binding affinity against proteins because of increased conformational rigidity and relatively preorganized structures, compared to their linear counterparts. Moreover, if they have a specific site like lipid chain, they may be used as antibiotics based on their characteristics. Daptomycin is a molecule consisting of 10 amino acids in cyclic form and a linear 3 amino acid side chain modified with an undecanoyl lipid at the N-terminus. And it has potent bactericidal activity with a unique mode of action against otherwise antibiotic-resistant Gram-positive pathogens. Thus, we envisioned to develop peptoid-based daptomycin analog which might have better bioactivity than daptomycin and might also resolve resistance problems. In this presentation, we will introduce synthetic studies on new peptoid analog of daptomycin on solid-phase.

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