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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly selective dual-channel fluorescent probe for sensing of Zn2+ ions and pyrophosphate in micelle

등록일
2017년 8월 10일 15시 55분 05초
접수번호
0280
발표코드
ORGN.P-263 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Min Jung Chang, Min Hee Lee1,*
Department of chemistry, Sookmyung Women's University, Korea
1Department of Chemistry, Sookmyung Women's University, Korea

Zn2+ is one of the significant cofactor in biological and pathological process such as brain function, gene trascription, immune function and Alzeimer’s diseases. Along with this essential metal ion, pyrophosphate (P2O74-, PPi) is also the most importantly biological involved anions in living systems. A lot of Zn2+-sensing and Zn2+ chelated PPi-sensing fluorescent probes have been developed. However, they suffered from poor limit of detection (LOD) and selectivity to Zn2+ and PPi, respectively. With this in mind, we reported a novel fluorescent probe 1, consists of naphthalimide as a fluorescence reporter, tetraphenylethene (TPE) as a well-known aggregation induced emission (AIE) fluorophore and dipicolyamino group as a zinc chelating ligand. To enhance the water solubility of 1 and its selectivity to Zn2+ ions, micelles were used to produce a micellar probe. This showed a weak fluorescence at 482 nm derived from TPE. Upon binding with Zn2+ in aqueous media at pH 7.4, a large fluorescence enhancement was observed at 530 nm due to an inhibition of photo-induced electron transfer (PET). Further addition of PPi, the fluorescence at 530 nm was gradually decreased while the fluorescence at 474 nm was increased. Thus, we found that the micellar probe 1 showed a high sensitivity and selectivity to Zn2+ even in the presence of other competitive biological metal ions along with 45 nM of LOD. Furthermore, the Zn2+-chelated probe 1 could be used for the detection of PPi among various anions.


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