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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Introduction of a New Hydroxybenzyne Precursors Induced by 1,3-Brook Rearrangement

등록일
2017년 8월 17일 17시 18분 33초
접수번호
0457
발표코드
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발표시간
목 09시 : 00분
발표형식
구두발표
발표분야
Organic Chemistry - Oral Presentations of Young Scholars in Organic Division
저자 및
공동저자
Yong-Ju Kwon, Wonsuk Kim1,*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
1Chemistry Department of Nano-Science, Ewha Womans University, Korea
Benzynes are highly strained and reactive alkynes and derived from an aromatic ring by removal of two ortho substituents. Because it has great activity and usefulness, a lot of attempt to make benzyne formation have been reported and especially, the method using silyaryl triflate in the presence of fluoride source has been employed. Herein, we report the design, synthesis and achievements of a new type of benzyne precursor which is capable of highly reactive benzyne intermediate induced by 1,3-silyl group migration on the aryl moiety. We would use this base-promoted benzyne generation method for the nucleophilic addition reaction and cycloaddition reaction and obtained meta-regioselective compounds in good to excellent yields. We also investigated plausible mechanism through previous reported method and crossover experiment.

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