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학술발표회초록보기

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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Pd-catalyzed Regioselective C−H Alkenylation of Pyrazoles

등록일
2017년 8월 18일 16시 44분 38초
접수번호
0556
발표코드
ORGN.O-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 30분
발표형식
구두발표
발표분야
Organic Chemistry - Oral Presentations of Young Scholars in Organic Division
저자 및
공동저자
HyunTae Kim, Jung Min Joo*
Department of Chemistry, Pusan National University, Korea

We have developed Pd-catalyzed regioselective C4-, C5-, and di-alkenylation of pyrazoles. Kinetic isotope effects and H/D exchange experiments were performed in order to obtain mechanistic insights into C4- and C5-alkenylation. These Pd-catalyzed protocols gave a wide range of alkenylated pyrazoles from readily available, inexpensive pyrazoles and alkenes. In addition, thermal 6-electrocyclization and oxidation via dialkenylated pyrazoles provided functionalized indazoles, which have important roles in medicinal chemistry and material science. Furthermore, C5-alkenyl pyrazoles were useful for the preparation of 3-alkenyl pyrazoles that are not easily accessible by C−H alkenylation. This comprehensive strategy can provide a variety of pyrazole and indazole derivatives for applications in the development of biologically active compounds and ]functional materials.


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