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제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Electrochemical detection of amyloid-β oligomers based on the signal application of nanostructured polypyrrole

등록일
2017년 8월 23일 16시 12분 40초
접수번호
1189
발표코드
ELEC.P-459 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Electrochemistry
저자 및
공동저자
JIELING QIN, Mi suk Cho, Youngkwan Lee*
School of Chemical Engineering, Sungkyunkwan University, Korea
In this work, a novel impedance sensor was developed based on a transducer of carboxyl end-capped polypyrrole nanostructure electrode and a probe of cellular prion protein (PrPc) selectively cognitive of amyloid-β oligomer. The nanostructured PPy was electrochemically synthesized by one step template-free polymerization and then, the carboxyl group was introduced by the addition of pyrrole-α-carboxylic acid, which was covalently coupled with the amine group of PrPc. The morphology of the PPy was confirmed by scanning electron microscopy. The modification and the electrochemical properties of the electrode were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The modified sensor provided to be highly sensitive to amyloid-β oligomer in a broad detection range of 0.00001-0.1 nM. The high selectivity and sensitivity of the Aβ oligomer sensor can be used in practical for the early diagnosis of Alzheimer’s disease.

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