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학술발표회초록보기

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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Redesigning the PEG Surface of Nanocarriers for Tumor Targeting

등록일
2017년 8월 24일 15시 53분 42초
접수번호
1893
발표코드
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발표시간
금 15시 : 00분
발표형식
구두발표
발표분야
Polymer Chemistry - Oral Presentation for Young Scholars in Polymer Chemistry
저자 및
공동저자
Yoonkyung Kim
Korea Research Institute of Bioscience and Biotechnology (한국생명공학연구원), Korea
Achieving accurate and efficacious tumor targeting with minimal off-target effects is of paramount importance in designing diagnostic and therapeutic agents for cancer. In this respect, nanocarriers have gained enormous popularity because of their attainable multifunctional features, as well as tumor-targeting potential by extravasation. However, once administered into the bloodstream, nanocarriers face various in vivo obstacles that may significantly impair their performance needed for clinical translation. Here, we demonstrate a strategy to enhance tumor-targeting efficiency by embedding functionalities in the interior region of partially PEGylated nanocarriers (ca. 10 nm in diameter) intended for active or passive targeting. The cooperative impact of these topologically inner functional groups (IFGs) was marked—enhancements of >100-fold in IC50 in vitro (e.g., a high-avidity ligand with cationic IFG) and >2-fold in tumor accumulation at 2 h post-injection in vivo (e.g., a high-avidity ligand with anionic IFG), both against the fully PEGylated counterpart. Analogous to allosteric modulators, properly employed IFGs may substantially improve the process of effectively directing nanocarriers to tumors, which is otherwise solely dependent on avidity or extravasation.

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