Magnetic resonance imaging (MRI) is one of the best noninvasive diagnostic modality in medical imaging. Gadolinium (Gd) complexes are widely used as longitudinal (T1) contrast agents (CAs). However, administration of Gd-based MRI CAs can generate serious side effects such as nephrogenic systemic fibrosis (NSF) in some patients. Mn(II) has five unpaired electrons, slow electron relaxation, fast water exchange kinetics and lower intrinsic toxicity than Gd3+, which makes it an attractive alternative of gadolinium(III) for enhanced MRI applications.
we design and synthesis a novel Mn2+ complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing an ethoxybenzyl (EOB) moiety with high chelation stability for use as a hepatobiliary agent. Also, we measured the magnetic and kinetic properties of Mn-EDTA-EOB complex in comparison, and liver and bile excretion pattern was confirmed through in vivo MR images, along with biodistribution of Mn-EDTA-EOB.