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제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and Evaluation of Mn-EDTA-EOB Conjugate as a new Hepatobiliary MRI Contrast Agent

2017년 8월 31일 16시 03분 17초
MEDI.P-363 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 19일 (목요일) 11:00~12:30
Medicinal Chemistry
저자 및
KAMRUL ISLAM, Hee Kyung Kim1, Soyeon Kim2, Choi Garam2, Ah Ruem Baek2, BoKyung Sung2, Byeong Woo Yang2, Seong hwan Hwang3, Yongmin Chang4,*
Medical & Biological Engineering, Kyungpook National University, Bangladesh
1Institute of Biomedical Engineering Research, Kyungpook National University, Korea
2Medical & Biological Engineering, Kyungpook National University, Korea
3Medical & Biology Engineering, Kyungpook National University, Korea
4Molecular Medicine, Kyungpook National University, Korea

Magnetic resonance imaging (MRI) is one of the best noninvasive diagnostic modality in medical imaging. Gadolinium (Gd) complexes are widely used as longitudinal (T1) contrast agents (CAs). However, administration of Gd-based MRI CAs can generate serious side effects such as nephrogenic systemic fibrosis (NSF) in some patients. Mn(II) has five unpaired electrons, slow electron relaxation, fast water exchange kinetics and lower intrinsic toxicity than Gd3+, which makes it an attractive alternative of gadolinium(III) for enhanced MRI applications. we design and synthesis a novel Mn2+ complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing an ethoxybenzyl (EOB) moiety with high chelation stability for use as a hepatobiliary agent. Also, we measured the magnetic and kinetic properties of Mn-EDTA-EOB complex in comparison, and liver and bile excretion pattern was confirmed through in vivo MR images, along with biodistribution of Mn-EDTA-EOB.