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학술발표회초록보기

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제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 SYNTHESIS AND BIOLOGICAL EVALUATION OF CHALCONE DERIVATIVES AS NEUROPROTECTIVE AGENTS FOR NEUROLOGICAL DISORDERS

등록일
2017년 8월 31일 15시 50분 16초
접수번호
2416
발표코드
MEDI.P-364 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Hyeon Ji Kim, Ki Duk Park*
Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Korea
Although the etiology of Parkinson’s disease (PD) is unclear, recent reported studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have synthesized novel chalcone derivatives to improve their Nrf2 activity and ADME/Tox profiles. Among the derivatives, compound 12d showed significant efficacy for activating Nrf2 and excellent profiles in ADME/Tox tests. In addition, compound 12d effectively protected DAergic neurons and attenuated PD-associated behavioral deficits in the MPTP-induced mouse model.

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