abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The Important Role of the Newly Formed Stereocenter on the Catalytic Activity of Proline Derived Bifunctional Organocatalysts

등록일
2017년 8월 31일 16시 33분 34초
접수번호
2422
발표코드
ORGN.P-440 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 20일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
HUI JIN, Cho Soo Min1, JUYEOL LEE1, do hyun ryu1,*
Department of Chemistry, Sungkyunkwan University, China
1Department of Chemistry, Sungkyunkwan University, Korea

As one of the most important classes of non-covalent organocatalysts, tertiary amine-(thio)urea organocatalysts have proven quite successful in accomplishing various asymmetric organic transformations. Recently, we reported a series of novel L-proline-derived tertiary amine bifunctional organocatalysts (PTU and PU), which were applied to asymmetric Michael additions to nitroolefins using dithiomalonates1 and 2-oxochroman-3-carboxylate esters2 as nucleophiles. In order to better understand the effects of the relative stereochemistry at C2/C6 on the catalytic activity, the C6 epimeric catalysts epi-PTU and epi-PU were newly synthesized and their catalytic performances were compared with PTU and PU in various Michael reactions of nitrostyrene in terms of reactivities and stereoselec-tivities.3 The experimental results indicate that a proper relative stereochemistry at C2 and C6 in L-proline-derived bifunctional organocatalysts is important for successful catalysis, and that catalysts (PTU and PU) with the 2S,6R configuration are much more efficient.


상단으로