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제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Heteroaromatic Sulfones: New Chemical Tools for Selective Detection of Biothiols

등록일
2017년 8월 31일 16시 59분 14초
접수번호
2441
발표코드
BIO.P-288 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Life Chemistry
저자 및
공동저자
Yu Rim Kwon, Chung-Min Park1,*
Department of Chemistry, Gangneung-Wonju National University, Korea
1Chemistry, Gangneung-Wonju National University, Korea
In biological studies, the selective reaction of chemical reagents with protein thiols is very important. This chemical reaction is employed to prevent cysteine-based cross-linking of proteins in common proteomics workflows. In addition, it is applied widely in targeted redox investigations of the mechanisms for understanding physiological and pathological processes in living systems. However, commonly used thiol blocking reagents like iodoacetamide (IAM), N-ethylmaleimide, and others were found to react with protein sulfenic acids (RSOH) which results in many significant errors in biological research. In this presentation, we will report a new heteroaromatic alkylsulfone, 4-(5-methanesulfonyl-[1,2,3,4]tetrazol-1-yl)-phenol (MSTP), as a selective and highly reactive biothiol blocking reagent for biological applications.

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