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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Virus based Novel Colorimetric Sensor for Cancer cell detection

등록일
2017년 9월 1일 13시 57분 27초
접수번호
2482
발표코드
POLY1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 00분
발표형식
심포지엄
발표분야
Polymer Chemistry - Human-friendly Polymers and Their Applications
저자 및
공동저자
Jin-Woo Oh
Department of Nanoenergy Engineering, Pusan National University, Korea

Color sensor like pregnancy test kit or litmus paper for pH test relies on color change depending on various chemical and physical conditions. Recently, we developed the novel colorimetric sensor which is functionalized with M-13 bacteriophage-based structure color [1], and it could detect TNT down to 300 p.p.b. over similarly structure chemicals [2]. Cancer cells release abnormal gas composition compared with that of normal cells. Therefore, cancer can be diagnosed by breath testing for a unique composition of volatile gas produced by each species of cells. Here, we developed the novel cancer recognition sensor suing virus-based structural color matrix. Due to its liquid crystalline behavior and surface modification ability, M-13 bacteriophage based color sensor exhibited remarkable selectivity and sensitivity to target samples including chemicals which compose VOCs of NCI. Upon exposure of small amounts of target molecules, the resulting colored matrices exhibited distinct different color changes that can be applied to effectively discriminate the target. Although the cancer cell sensing system was used as proof-of-concept in this study, this approach can be generalized to the detection of many harmful and biological toxicants.


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