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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and biological evaluation of guggulsterone derivatives as kidney cell protective agents

등록일
2017년 9월 3일 17시 19분 04초
접수번호
2485
발표코드
MEDI.P-367 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
TAEJUNG KIM, Dong Hoi KIM1, Jungyeob Ham, Heesu lee2, Ki Sung Kang3, Jae Wook Lee4,*
Natural Products Research, Korea Institute of Science and Technology, Korea
1Research Center for Dementia DTC, Korea Institute of Science and Technology, Korea
2Department of Dentistry, Gangneung-Wonju National University, Korea
3Department of Oriental Medicine, Gachon University Global Campus, Korea
4Convergence Research Center for Dementia DTC, Korea Institute of Science and Technology, Korea
We synthesized guggulsterone derivatives using [3+2] click reaction with aryl and alkyl acetylene with relatively high yields. These synthesized derivatives were evaluated for kidney cell protection effects against cisplatin toxicity. cisplatin is known as anticancer agent. However, cisplatin induced severe side effects to kidney cells by increasing oxidative stress. Therefore, cisplatin treatment is generally used for chronic kidney disease model. In this research, we evaluated kidney cell protective effects of gugglusterone derivatives. Among these guggulsterone derivatives, 6g which has hydroxyl group show protection effects. It is known that cellular oxidative stress induces MAPK kinase signal pathway and caspase activation. We therefore investigated if 6g reduces these signal cascades. We further investigate population of live of dead cells after treatment of 6g. These data indicated that inhibition of the mitogen-activated protein kinase/caspase-3 signaling cascade by 6g mediates its protective effects against cytotoxicity in cultured LLC-PK1 kidney cells.

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