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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Bidentate Directing Group: Versatile Platform for C–H Activation and Privileged Building Blocks

2017년 9월 3일 18시 19분 03초
KCS3-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
수 16시 : 40분
KCS - [IBS Symposium] Developing New Catalytic Organic Reactions and Investigating Their Applications
저자 및
Sungwoo Hong
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
Solutions to problems that are posed by organic, medicinal, biological and material science, demand synthetic innovation with efficient synthetic routes. Our current research is focused on studying breakthrough knowledge in catalytic synthetic methods and molecular design that have high impact on broader scientific fields. The selective C–H bond functionalization has become the favored reaction methods in practical synthetic processes. The new catalytic synthetic methods allow us to perform the unprecedented disconnection of target molecules, affording innovative and imaginative synthetic strategies of so-called “privileged scaffolds”. The power and efficiency of direct C–H functionalization could be further enhanced by combining such catalytic transformations into a one-pot process, which is highly desirable by providing a powerful platform for constructing complicated key motifs from simple starting materials. Subsequent medicinal chemistry studies involving a modular approach and privileged fragments assembly, will provide bases for the development of pharmaceutical agents via structure-based design. The new catalytic synthetic methods will function as competent tools directly utilized in cross coupling reactions capable of connecting privileged building blocks, providing opportunities for the successful implementation of fragment-based drug design (FBDD) and eventually streamline drug discovery research.