Meetings
Home      학술발표회 - 초록 상세보기

  학술발표회 - 초록 상세보기

문의 : 초록( abstract@kcsnet.or.kr), 참가비( member@kcsnet.or.kr)

 

현재 가능한 작업은 아래와 같습니다.

  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
등록일 2017년 09월 05일 16시 49분 07초
접수번호 2507
발표코드 MEDI.P-371 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간 10월 19일 (목요일) 11:00~12:30
발표형식 포스터
발표분야 Medicinal Chemistry
저자 및 공동저자 jaemoon lee, Jae Pil Kim1,*
Department of Material Engineering, Seoul National University, Korea
1Division of Material Engineering, Seoul National University, Korea
제목 Novel photosensitizers for photodynamic therapy(PDT) based on aggregation induced emission enhancement(AIEE) and thermally activated delayed fluorescence(TADF)
내용 The hydrophobic nature of conventional photosensitizers makes it difficult for PSs to disperse and even causes PSs to aggregate in aqueous physiological environment. In aggregates, the planar structure of PSs maximizes the π-π intermolecular interactions and thus greatly contributes H-aggregation which reduces efficiencies of fluorescence and singlet oxygen generation, namely aggregation caused quenching(ACQ) To address this problem, considerable attention has been focused on aggregation induced emission enhancement(AIEE) in photoluminescence research area. Unlike aggregation caused quenching, by their unique rotating geometry, AIE(E) aggregates exhibit high fluorescence with increasing concentration, even in aqueous physiological environment. Aggregation induced photodynamic therapy enhancement(AIPE) inspired by AIE(E) has been studied last two years and several groups showed AIPE photosensitizers could be a promising therapeutic strategy for photodynamic therapy. Our group synthesized novel photosensitizers based on boron dipyrromethane(BODIPY) derivatives and confirmed aggregation induced photodynamic therapy enhancement(AIPE) and emission enhancement(AIEE) of these photosensitizers. Triphenylamine(TPA) moieties were introduced on a BODIPY core for an AIPE and thermally activated delayed fluorescence(TADF) phenomenons. The high-angle between donor and accepter of BODIPY induced to separate electron distribution in HOMO and LUMO, induced singlet oxygen generation without bromine. To gain further insights into the results, The optimized structures, electron distributions of all the dyes were calculated, using the density functional theory(DFT) B3LYP/6-31G(d,p) level.
- 등록된 그림이 있는경우 그림을 클릭하시면 원본 그림파일을 볼 수 있습니다.
- 최종본을 확인하지 않아 발생된 문제에 대해서는 책임지지 않습니다.
- 미리보기의 그림위치는 임시 위치입니다. 모든 그림파일은 Abstract 하단에 위치하게 됩니다.
목록