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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Analysis of Correlation between Structure of Linear Surfactants and Acute Eye Irritation Scores

2017년 7월 30일 15시 53분 28초
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목 09시 : 22분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
Sujin Cho, Tian Tian, Seog Woo Rhee*
Department of Chemistry, Kongju National University, Korea
In this work, we determined the eye irritation scores of surfactants with linear alkyl chains by HET-CAM assay using hen’s eggs and investigated the correlation between the structure of surfactants and eye irritation scores. Surfactants with a cationic (ammonium salt), neutral, anionic (sulfate) head groups and a linear alkyl chain with 8 to 16 carbons as the tail group were selected. The properties of surfactant forming micelles in aqueous solution were measured by an electrical conductivity method and an absorbance measurement method. The eye irritation scores of surfactants at various concentrations were measured by the HET-CAM assay using hen’s eggs as an alternative animal test. Based on the experimental results, we found a significant correlation between the structural properties of the surfactant and the critical micelle concentration, and the acute irritation score of the surfactant. The results of this study will be used to develop cell-based devices using microfluidic chips that can replace the HET-CAM assay.