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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Effect of high fat diet on mouse brain lipidomes by nUPLC-ESI-MS/MS : Cortex, Hippocampus, Hypothalamus, & Olfactory bulb

2017년 8월 22일 15시 53분 35초
ANAL1.O-24 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 07분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
JongCheol Lee, Myeong Hee Moon*
Department of Chemistry, Yonsei University, Korea
Lipids are known to be involved in various neuronal functions in brain, which is one of the most important and complex organ in the central nervous system. As brain plays a number of roles including cognition, memory, learning, and metabolic control, brain dysfunction can eventually lead to a variety of diseases. Recently, lipidomic analysis in relation to brain diseases has attracted much attention. High fat diet (HFD) can cause insulin resistance in the brain tissues by inducing obesity through diet. Although the effects of HFD on brain health have been studied in pathology, the relationship between HFD and brain lipid profiles has not been extensively studied. In this study, four different brain tissues (cortex, hippocampus, hypothalamus, and olfactory bulb) from mouse upon high fat diet programs have been analyzed using nanoflow ultrahigh pressure LC-ESI-MS/MS (nUPLC-ESI-MS/MS) for the investigation of HFD effect on the changes in the lipid profiles. Mice were fed with the various dietary plans: 8 weeks normal control (N), and weight gain (F), 16 weeks normal control (NNN), weight maintenance (FNN), weight gatin (NNF), and weight cycling (FNF), As a result, 270 lipids including phospholipid, glycerolipid, and sphingolipid were quantified and statistical analysis was applied.