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09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Profiling of lipoproteins from patients with mild cognition impairment and Alzheimer’s disease by asymmetrical flow field-flow fractionation and nUPLC-ESI-MS/MS
2017년 8월 22일 15시 55분 34초
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목 10시 : 13분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists I
SAN HA KIM
, JoonSeon Yang
, Myeong Hee Moon
Department of Chemistry, Yonsei University, Korea
Recently, as the average life span of people is increasing, the number of elderly population has been rising sharply and cognitive impairment disorders with aging factor such as Alzheimer’s disease have become common. Amyloid-beta plaques is known to be a major cause of Alzheimer’s disease and kills neighboring brain cells, which leads to dysfunction in cognitive abilities. Symptoms of Alzheimer’s disease’s are usually developed decades after the accumulation of amyloid-beta. Therefore, the rate of disease progression is even faster when symptoms start to appear. About 10 percent of patients with mild cognitive imparirment, a pre-stage of Alzheimer’s disease, end up diagnosed with Alzheimer’s disease within a year. Several studies have reported that high levels of low-density lipoprotein(LDL) and low levels of high-density lipoprotein(HDL) is affected amyloid-beta. Therefore, it is important to understand lipid metabolism from separating HDL and LDL, separately. In this study, lipids from human plasma samples of healthy controls, patients with mild cognition impairment, and Alzheimer’s disease patients were analyzed. Lipoproteins were fractionated by asymmetrical flow-field flow fractionation and the lipids were extracted from the collected fractions of HDL and LDL and structurally identified from collision-induced dissociation of nanoflow ultrahigh-pressure liquid chromatography-electrospray ionization-tandem mass spectrometry (nUPLC-ESI-MS/MS). More than 300 lipids were identified. Identified lipids are quantified from individual samples to evaluate the difference between the two groups in comparison to those of healthy controls.
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