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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Lipidomic analysis of blood plasma from patients among five differentcancer typesby nUPLC-ESI-MS/MS

2017년 8월 22일 16시 38분 09초
ANAL1.O-28 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 15분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
Gwang Bin Lee, JongCheol Lee, Myeong Hee Moon*
Department of Chemistry, Yonsei University, Korea
As lipids area associated with functions such as chemical-energy storage, cellular signaling, cell membranes, and cell to cell interaction, they play a key role in cellular survival, proliferation, and death. These cellular processes are vitally concerned with carcinogenesis pathways, especially to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. According to recent lipidomics research, lipid analysis regarding canceris very important, since each type of cancer has different carcinogenesis pathways. In this study, lipids from plasma of healthy controls and patients with cancers (liver, stomach, lung, colorectal, and thyroid) were investigated in order to discover lipids that show significant difference between the groups and find potential lipid biomarkers for each cancer. Blood plasma were extracted from each control and cancer patients using the modified Folch method with MTBE/methanol, and the extracted lipids were analyzed by nLC-ESI-MS/MS. A total of 243, 236, 239, 239, 239, and 225 lipids from plasma of patients with liver, stomach, lung, colorectal, thyroid cancer, and controls, respectively, were identified and profiling of lipid from each case of cancer was compared with that of controls.