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09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Identification of Diverse Types of Monosaccharide Derivative Isomers By Host-guest Complexation with Cucurbituril
2017년 8월 30일 10시 38분 54초
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금 10시 : 17분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
Hyun Hee L. Lee
, Hugh Inkon Kim
Department of Chemistry, Korea University, Korea
Distinguishing constituent monosaccharides in target carbohydrate using mass spectrometry (MS) remains challenging due to their undistinguishable fragmentation patterns induced by their isomeric structures and similar physical properties. Although a carbohydrate is composed of diverse monosaccharide/monosaccharide derivative species, previous methods focused on one or two types of monosaccharides and monosaccharide derivatives. Therefore, it is necessary to invent a novel approach to be developed as a comprehensive method for identification of diverse types of monosaccharides and monosaccharide derivatives. Our study reveals that the combination between host-guest and gas-phase chemistry is effective for identifying diverse types of monosaccharide derivative isomers. Four different types of monosaccharide derivative isomers were investigated herein as target monosaccharide derivative species. A host molecule, cucurbituril (CB), was utilized herein due to its high recognition ability in monosaccharides. It was observed that each monosaccharide derivative forms gas-phase complex with CB while most of bindings between the CB and target guests are negligible in aqueous solution. Tandem MS study shows that the monosaccharide derivatives have different fragmentation patterns in their complexes with CB, allowing their identification. Structural studies using ion mobility MS and computational calculations suggest that the slight structural differences between the isomers are augmented by their distinct host-guest interactions with CB in the gas-phase. Overall, the present study reveals that our gas-phase host-guest system can be developed as a comprehensive method for qualitative analysis of constituent monosaccharides in target carbohydrates.
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