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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rapid and sensitive detection of highly risk pathogens using SERS-based lateral flow assay

2017년 8월 31일 09시 55분 58초
ANAL2.O-33 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 25분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Kihyun Kim, Rui Wang, JAEBUM CHOO*
Department of Bionano Technology, Hanyang University, Korea
Bioterrorism has been received great concerns after the 2001 anthrax attacks in United States. Highly risk pathogens used in the bioterror are greatly contagious and also have a high fatality. To minimize life damages from bioterror, rapid and sensitive detection methods of specific pathogen is urgently required. To date, various detection methods including direct counting of bacteria, polymerase chain reaction (PCR), and immunoassay have been developed but they do not satisfy the requirements in the field due to complicated sample pre-treatment procedures, long detection time and low sensitivity. To resolve those problems, we recently developed a SERS-based detection technique for the detection of various pathogens. In this poster, we introduce a new pathogen assay method using a SERS-based lateral flow assay. Two different pathogens, Bacillus anthracis and Francisella tularensis have been selected as detection targets. In the case of Francisella tularensis, the limit of detection measured by the SERS-based lateral flow platform was estimated to be 102 CFU/mL, which is three orders of magnitude more sensitive than that of commercial ELISA kit. Therefore, the proposed SERS-based lateral flow assay technique has a strong potential to be used as a valuable tool in the early detection of a specific pathogen due to its simplicity and excellent analytical sensitivity.