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09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Metabolic profiling in heart tissue of mice fed atherogenic diet
2017년 8월 31일 13시 20분 35초
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금 10시 : 35분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
, do hyun ryu
, Geum-Sook Hwang
Department of Chemistry, Sungkyunkwan University, Korea
Korea Basic Science Institute, Korea
Atherosclerosis is a leading cause of cardiovascular disease characterized by thickening of the arterial wall resulting from abnormal lipid accumulation. In atherosclerosis model, most of the studies illustrated the mechanism of atherosclerosis in biofluids and/or liver but not in heart. In the present study, we performed metabolic profile in heart tissue during the progression of diet-induced atherosclerosis mouse model using liquid chromatography/mass spectrometry (LC/MS). A lipidomics approach was used to investigate the changes in lipid species in heart tissue from AD mice. Principal component analysis (PCA) plots showed a clear differentiation between normal diet (ND) and atherogenic diet (AD) groups in both positive and negative ion modes. In the PCA score plots, significant discriminations between ND and AD groups was observed in each time point (8 weeks, 16 weeks, and 25 weeks). Cers were significantly decreased in AD group, whereas GlcCers were increased in AD group. Saturated fatty acids including FFA 16:0 (palmitic acid) and FFA 18:0 (stearic acid) were significantly increased in AD, whereas unsaturated fatty acids were decreased. TG species were changed depending on the length of acyl chain and degree of unsaturation. Also we assessed quantitative analysis of suffer-containing amino acid (SAA) metabolites which is related with stearoyl-CoA desaturase-1 (SCD1) because SCD1 produces monounsaturated fatty acids from saturated fatty acids. The levels of SAA metabolites in heart tissue were significantly changed in AD mice. This study demonstrates that LC/ MS based metabolic profiling can be used to understand metabolism in heart tissue of diet-induced atherosclerosis animal model and may provide the insight for molecular aspects of cardiovascular diseases.
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