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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Facile Fabrication of Nanostructured Surfaces Amenable to Laser Desorption/Ionization of Drug Molecules

2017년 8월 31일 14시 12분 59초
ANAL2.O-39 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 37분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
SEUNGMOH LEE, Sang Jun Son1,*, Sang Yun Han2,*
Nano chemistry, Gachon University, Korea
1College of Bio Nano Technology, Gachon University Global Campus, Korea
2Department of Nano Chemistry, Gachon University Global Campus, Korea
Herein, we present a facile strategy to bring the LDI (laser desorption/ionization) capability onto nanostructured surfaces, which can further be tailored with various surface coatings suitable to individual applications. While the MALDI (matrix-assisted laser desorption/ionization) method has been a powerful tool to ionize thermally labile molecules such as biological and synthetic polymers, the intrinsic use of excess matrixes causes certain limitations on its applications. To overcome the related issues, matrix-free LDI methods have been demonstrated in recent years; in particular, a variety of nanostructures were exhibited for their LDI capability, most of which are unfortunately too special to be prepared by other laboratories. In this presentation, we present a simple and facile strategy of how to get certain surface nanostructures to achieve the LDI capability by using known techniques of surface chemistry. The strategy is based on the thermal mechanism that would promote intact desorption of thermally labile molecules by laser-induced surface heating. The produced LDI nanostructured surfaces can further be decorated by surface coatings to possess the suitable surface properties for individual applications, such as hydrophobic, hydrophilic, and non-fowling properties. All these can be done by simple and known chemistry. In addition, this strategy is applicable to virtually any nanostructured surfaces. In this work, the strategy is demonstrated on conical AAO (anodized aluminum oxide) templates with respect to LDI of drug molecules with moderate molecular weights of 500 to 1000 Da.