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제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Metabolomic analysis of polychlorinated biphenyls(PCBs) and organochlorine pesticides(OCPs) exposure in human plasma

2017년 8월 31일 15시 08분 33초
ANAL2.O-40 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 39분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Seoyoung Jang, Geum-Sook Hwang1,*
Chemistry nano science, Ewha Womans University, Korea
1Korea Basic Science Institute, Korea
Polychlorinated biphenyls(PCBs) and organochlorine pesticides(OCPs) are types of persistent organic pollutants (POPs) known as lipophilic environmental toxins. Accumulation of POPs has adverse effects on both environment and human. However, few studies have assessed their internal exposure to POPs. The objective of this study was to observe the effect by accumulation of POPs in humans and to investigate the associations between POPs levels and metabolic profiles in plasma samples. In this study, concentrations of total 33 POPs including 16 PCBs and 17 OCPs were analyzed from plasma samples of 300 Koreans without occupational exposure to POPs. The sum of the signed ranks of five PCBs and six OCPs, respectively, were used in multivariate regression tools adjusted for age, sex, BMI, education, smoking and alcohol intake. Then, we performed plasma metabolic profiling using 1H-NMR spectroscopy. We found that PCBs were significantly associatedcorrelated with creatine, glucose, mannose, citrate, and phenylalanine. On the other hands, OCPs were correlated with creatine, mannose, lactate, and phenylalanine. This study suggests that the NMR-based metabolomic approach may provide a promising technique to understand the alteration of human metabolism and to identify potential biomarkers for estimating exposure effect of environmental toxins like POPs.