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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development and Bioactivity Evaluation of New Anticonvulsants

등록일
2018년 1월 30일 11시 39분 59초
접수번호
3384
발표코드
BIO.O-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 00분
발표형식
구두발표
발표분야
Life Chemistry - Oral Presentation in Chemistry of Life
저자 및
공동저자
songmi Bae, Ju Hyun Song, Dai Il Jung*, JUNGTAI HAHN1
Department of Chemistry, Dong-A University, Korea
1Department of Beauty Care, U1 University, Korea
The human brain is the source of human epilepsy. Epilepsy is a chronic disorder, the hallmark of which is recurrent, unprovoked seizures. The seizures in epilepsy may be related to a brain injury or a family tendency, but often the cause is completely unknown. The exact mechanism of epilepsy is unknown, but a little is known about its cellular and network mechanisms. In connection with the development of new anticonvulsant, we examined the structural similarities of various anticonvulsants, known to act by different mechanisms. So we designed the active structure such as ester or acid anhydride in a single molecule as new anticonvulsant of broader spectrum. Herein we wish to report the synthesis of a series of valproic acid and their in vivo and in vitro anticonvulsant evaluations.

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