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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제121회 학술발표회 및 총회 DNA-functionalized Gold Nanodimers for Monitoring Rotation dynamics of single lipid molecule on supported lipid bilayer

2018년 2월 7일 10시 05분 09초
INOR.P-108 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
Youngchan Park, HyeongGyu Jin1, Hyunjoon Song*, Daeha Seo1,*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
1Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
Enzyme-coupled receptor protein such as EGFR has been known that activation for internal signaling is induced by receptor dimerization. During dimerization, transmembrane domains of the two receptors are twisted each other for further intracellular signaling. One of the suggestions regarding to the mechanism is, yet controversial, that rotation of proteins plays vital role in twisting process. However, lack of proper imaging probe for monitoring of rotation dynamics on living cell, almost none of studies are demonstrated regarding to rotation of transmembrane proteins. We fabricated valency-controlled asymmetric gold nanoprobe using DNA functionalization on nanoparticle surface. Gold probes were tested on supported lipid bilayer as a model system and we successfully monitor the rotation of lipid molecules. Lateral and rotational diffusivity is measured and the values are found to be independent to each other. Application of the probes to live cell will pave the way of understanding rotation dynamics of various biomolecules including lipids and membrane proteins.