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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제121회 학술발표회 및 총회 Single cell manipulation by magnetic nanoparticle cloaking

2018년 2월 7일 10시 06분 13초
INOR.P-109 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
Jiseong Park, Daeha Seo*
Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
Although most of the research on cellular phenotype has focused on genetic and chemical factors, physical parameters such as diffusion dynamics, density of cells and distance between cells are non-negligible factors because of complex signaling network of cells. To manipulate physical parameters, mechanical force generator at the cellular level is needed. Magnetic nanoparticles (MNPs) can be a good tool to solve some biological questions due to their inherent magnetic property. Herein, we synthesized MNPs and conducted additional surface chemistry to ensure the dispersion stability of MNPs in aqueous phase and to prevent nonspecific binding with other biomolecules. Due to the non-interfering property of cloaking nanoparticles, it can manipulate single cells without affecting the original function of cellular components. Also, by using the functional groups obtained from surface chemistry, MNPs are conjugated with gold nanoparticles that show optical properties in visible region. We confirmed optical properties of the hybrid nanoparticle by using dark-field scattering microscopy. The hybrid structure will be advantageous for studying the mechanisms of various phenomena at the single molecular level as well as at the single cellular level.