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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제121회 학술발표회 및 총회 Chemical Toolkit for Spatiotemporal-Quantitative Manipulation of Intracellular Signaling

2018년 2월 7일 10시 54분 12초
INOR.P-117 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
Sangwon Shin, Jaeheung Cho1,*, Daeha Seo*
Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
1Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
Systems biology is a collective understanding of the composition, relationships, interactions, and dynamics of the components that make up the system in which biological phenomena occur, in order to uncover the fundamental principles governing complex life phenomena. System biology requires tools that can regulate the activity of molecules and proteins in the cell, both spatiotemporally and quantitatively, as well as biological sensors that can measure the output of cell signals. We synthesized inorganic compounds that have photolytic ligands to activate target cell signal and constructed biological sensors through plasmid cloning and transfection. The cell permeable cobalt complex [CoⅢ(MDAP)(CH3CN)(NO)](ClO4)2 releases NO by receiving light in the cell, which activates the ERK signal in the cell. By activating the ERK signal of the biological sensor model cell, the change of the cell signal can be observed in real time by fluorescence microscopy. It is based on the study of system biology by enabling spatiotemporal and quantitative regulation of cells and observing changes in cellular signals.