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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Effects of the Ligand Structure of Cu(II) Complexes on Oxidative DNA Cleavage

2018년 2월 7일 16시 11분 05초
INOR.P-176 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
Seog K. Kim*, Ji-Hoon Kim1, Yoon-Jung Jang2, Hyosun Lee1, Maeng-Joon Jung1
Department of Chemistry, Yeungnam University, Korea
1Department of Chemistry, Kyungpook National University, Korea
2College of Basic Education, Yeungnam University, Korea

Abstract Cu complexes were synthesized by substituting the hydrogen of the amine group of basic ligand 2, 2'-dipicoylamine (dpca) (complex 2) with CH3CO (complex 1), phenyl (complex 3), and methyl (complex 4), respectively, and their DNA cleavage activity was investigated using linear dichroism (LD) and electrophoresis. The DNA cleavage efficiencies of Cu complexes 3 and 4 with phenyl and methyl, which are electron-donating functional groups, turned out to be the highest, and LD magnitudes rapidly decreased at 260 nm. In particular, Cu complex 3 showed a rapid LD magnitude reduction to 63% of the total for 90 minutes, and to 50% of the total at 12 minutes. DNA cleavage efficiencies were high in the order of phenyl > methyl >H = CH3CO, and the highest DNA cleavage efficiency was observed in the presence of electron-donating groups. The electrophoresis results are also consistent with the changes in LD spectra over time. The Cu complexes (1-4) were found to cleave DNA through oxidative pathways, and the major ROS involved in DNA cleavage were the superoxide radical, singlet oxygen and hydroxyl radical.