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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Exploration of Phosphite Based Reductive Ligation of S-nitrosothiols

등록일
2018년 2월 13일 10시 23분 08초
접수번호
5941
발표코드
ORGN.P-545 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Chung-Min Park
Chemistry, Gangneung-Wonju National University, Korea
S-Nitrosylation is a nitric oxide (NO)-mediated post-translational modification (PTM), which plays important regulatory roles in many biological systems. Although a large number of proteins have been suggested to be the targets of S-nitrosylation, the detection of S-nitrosylation is still a challenge. In the past several years bioorthogonal reactions of SNO with various phosphines have been aimed at developing new methods for detecting and labeling protein S-nitrosothiols. As it is known that azaylides as the key intermediates in these reactions can also be generated from phosphite substrates, we wondered if phosphites could be used to trap SNO. Here we present that the reaction with phosphites is selective for SNO (not for -SH, –S-S-, etc) like phosphine based ligations, but the products should be very different from the reactions with phosphine substrates.

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