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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of new heterocyclic 4,5-dimethylthiazolium salts as a candidate of AGE-breaker

등록일
2018년 2월 13일 11시 04분 11초
접수번호
5946
발표코드
ORGN.P-546 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
JiSue Lee, Inseok ko1, Hakwon Kim*
Department of Applied Chemistry, Kyung Hee University, Korea
1Department of Chemistry, Kyung Hee University, Korea

Advanced glycation end-products (AGEs) are proteins or lipids that become glycated as a result of exposure of sugars. They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer’s diseases. Alagebrium (or ALT-711) and its analogs which have a 4,5-dimethylthiazolium moiety were known as AGE-breakers to break up some existing AGE crosslinks. In this work, we have synthesized new 4,5-dimethylthiazolium salts containing heterocyclic moieties as the AGE-breaker.


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