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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Novel synthesis of 1,4-naphthoquinone derivatives and its biological evaluation

등록일
2018년 2월 13일 11시 04분 10초
접수번호
5956
발표코드
ORGN.P-550 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
eunyeong lee, Inseok ko1, hyunjin lee2, TAEHOON LEE2, Hakwon Kim2,*
applied chemistry, Kyung Hee University, Korea
1Department of Chemistry, Kyung Hee University, Korea
2Department of Applied Chemistry, Kyung Hee University, Korea

Quinone moieties are widely distributed in nature and are the key pharmacophore of many clinically important drugs, such as anthracycline, daunorubicin, doxorubicin, mitomycin, mitoanthrone, and saintopin. Among the quinone derivatives, 2,3-disbustituted- 1,4-naphthoquinone show many interesting biological activities such as antitumor, antimalarial, antibacterial etc. Therefore, we have synthesized various 2,3-disubtituted-1,4-naphthoquinone derivatives. We have evaluated the effect of 2,3-heterocyclic-1,4-naphthoquinones on the survival of various cancer cell lines, and furthermore, we have verified the biological activity against anti-cancer immunotherapies.


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