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제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Molecular genetic insights of a pleiotropic neuropeptide myoinhbitory peptide

2018년 2월 13일 11시 51분 46초
BIO3-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 00분
Life Chemistry - Current Trends in Biological Chemistry
저자 및
Young-Joon Kim
School of Life Sciences, Gwangju Institute of Science and Technology, Korea
The neuropeptide represents the most ancient type of signaling molecules, critical for intercellular communications underlying a plethora of biological processes. Here, I discuss a series of our studies using Drosophila melanogaster, a genetically amendable animal model, which together uncover molecular and neural mechanisms underlying the functional pleiotropy of a neuropeptide myoinhibitory peptide (MIP). We discovered that MIP regulates at least three distinct biological processes; sleep, feeding, and mating. We showed earlier that MIP is a potent ligand for the sex peptide receptor (SPR), which initially identified as a receptor for sex peptide (SP), the seminal protein evoking the post-mating responses in females. Unlike SP, MIP is not involved in the post-mating responses. Instead, both MIP and SPR are critical for consolidating the sleep state. We also uncovered MIP signal is crucial for the satiety. Mip mutant is hardly satiated after feeding and become obese. Unlike sleep behavior, however, SPR seems not involved in the MIP-dependent satiety responses, suggesting that MIP signals through a receptor(s) other than SPR. Lastly and the most recently, we have shown that Mip promotes mating receptivity both in virgins and mated females, again SPR-independently. We mapped each of these biological functions to three distinct groups of MIP neurons, respectively. We propose that a pleiotropic neuropeptide regulates multiple functions via distinct receptors.