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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Separation of Racemic Omeprazole by Chiral Capillary Electrophoresis based on UV Detection

등록일
2018년 2월 13일 12시 17분 22초
접수번호
5986
발표코드
ANAL.P-304 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터 분석구두발표
발표분야
Analytical Chemistry
저자 및
공동저자
GeonBok Lee, Minjeong Gu1, Seong Ho Kang*
Department of Applied Chemistry, Kyung Hee University, Korea
1Department of Chemistry, Kyung Hee University, Korea
Separation of (S), (R)-omeprazole which is a medication for the treatment of gastroesophageal reflux disease and peptic ulcer disease was performed on a lab-built capillary electrophoresis (CE) system coupled with a ultraviolet (UV) detector at 301 nm. In this study, 2-hydroxypropyl β-cyclodextrin (HP-β-CD) dissolved in 20 mM phosphate buffer (pH 6.0) was used as the chiral additive and the identification of omeprazole enantiomers dissolved in stock solution (CH3OH : NaOH = 9 : 1, v/v) was carried on the capillary with a total length of 40 cm and effective length of 25 cm based on capillary zone electrophoresis. Analysis times, shorter than 16 min were found using a background electrolyte solution consisting of 20 mM phosphate buffer conditioned to pH 6.0, 40 mM HP-β-CD, hydrodynamic injection (siphoning), and 15 kV separation voltage.

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