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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제121회 학술발표회 및 총회 Ultrastable cross-bridged chelators as general platform for antibody radiolabeling with Cu-64

등록일
2018년 2월 13일 14시 26분 06초
접수번호
6016
발표코드
INOR.P-205 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Inorganic Chemistry
저자 및
공동저자
Swarbhanu Sarkar, Rammyani Pal1, Yeong Su Ha1, Phoung Tu Huynh1, Woonghee Lee1, Jung-Min Jung1, JUNG-YOUNG KIM2, Kyo-Chul Lee2, Jeongsoo Yoo1,*
Molecular Medicine, School of Medicine, Kyungpook National University, Korea
1Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Korea
2RI-Convergence Research, Korea Institute of Radiological & Medical Science, Korea
Monoclonal antibodies have been widely exploited for both diagnostic and therapeutic purposes. For antibody radiolabeling with Cu-64, requirement of a bifunctional chelator which can hold the radio metal robustly is essential. Thus development of ultrastable chelator is needed. However, most heat-sensitive antibodies cannot be radiolabeled utilizing these chelators because of their high temperature radiolabeling profile. It thus limits its wide applications. Herein we develop a new type of versatile cross-bridged macrocyclic chelator (PCB-TE2A-alkyne), which can be transformed to any functional group prior to radiolabeling for easy conjugation with antibody. Modifications to different functionality did not require any tedious purification and after radiolabeling it can be conjugated to antibody in excellent yield. It thus facilitates a general and broad platform for antibody radiolabeling with Cu-64. The applicability was demonstrated using trastuzumab in NIH3T6.7 tumor-bearing BALB/c nude mice.

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