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학술발표회초록보기

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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Novel fluorophores based on “Click chemistry” through sulfur fluoride exchange (SuFEx) reactions

등록일
2018년 2월 13일 16시 10분 37초
접수번호
6117
발표코드
ORGN.P-561 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jisu Park, Byeong Moon Kim*
Division of Chemistry, Seoul National University, Korea

Chemical biology is essential for the study of biological processes in the living system. Especially, site-specific biomolecule functionalization strategies such as spin probes and affinity tags have been greatly utilized for understanding biological system. However, a few drawbacks including side reactions and non-site-specific labeling have been reported. Therefore, bioorthogonal reactions have been devised to tag biological targets within complex living systems. Among those, one of the most powerful methods includes the use of “Click chemistry” such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC) and tetrazine-trans-cyclooctene ligation. On the other hand, these reactions still have problems in relation with unwanted metal residue, slow reaction rate and chemical instability. Recently, Sharpless et al. discovered a valuable new click reaction for biological chemistry, i.e. sulfur(VI) fluoride exchange (SuFEx) reaction. Herein, we report the effectiveness of the fosylate flurophores as reactive probes in chemical biology and introduce two applications; biorthogonal modification of the side chain of tyrosine derivatives and mitochondria-targeted tracker.


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