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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제121회 학술발표회 및 총회 Triethylammonium-bearing cyanostilbene-based fluorescent probe for the detection of hydroxyl radicals

2018년 2월 13일 16시 46분 50초
INOR.P-218 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
Na Young Lim, Junho Ahn, Jong Hwa Jung*
Department of Chemistry, Gyeongsang National University, Korea
Reactive oxygen species (ROS) is generated by photochemical reactions, enzymatic reactions in the body, and has a critical effect on cells. ROS attacks irreversibly and nonselectively the biopolymers in cells, causing oxidative damage and inducing apoptosis in cells. It is also known to cause various diseases such as cancer, immune diseases, degenerative brain diseases, and pakinson's disease. Typical reactive oxygen species are hydrogen peroxide (H2O2), superoxide ion (O2-), and hydroxyl radical (OH). Among them, it is known that the activity of hydroxyl radical is the highest, which is a great risk. Thus, we synthesized the novel fluorescent probe L1 for detection of hydroxyl radicals. we designed molecules in which the electron donor was placed at the phenyl moiety of cyanostilbene. Consequently the fluorescence of the dye should be efficiently quenched. Reaction with hydroxyl radical should cause cleavage of the ether moiety, which is highly fluorescent in an aqueous environment. The reactivity of L1 in the presence of various ROS (O2-, H2O2, ClO-, GSH, TBHP, NO, OH) were confirmed in sodium phosphate buffer. Fluorescence intensity increased selectively in presence of hydroxyl radicals, On the other hand, fluorescence intensity did not increase when other ROS was present. We will further study the properties of L1 and its in vivo properties for hydroxyl radicals