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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Improved Maltose Neopentyl Glycol Amphiphiles for Membrane Protein Stability

등록일
2018년 2월 14일 16시 53분 57초
접수번호
6205
발표코드
ORGN.P-574 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
HYOUNG EUN BAE, Pil Seok Chae*
Department of Bionano Engineering, Hanyang University, Korea
Detergents are widely used in membrane protein research, particularly for membrane protein structural studies. However, many membrane proteins tend to aggregate or denature with time when solubilized in a conventional detergent, necessitating the development of new agents with distinct architecture and enhanced efficacy. Over the past few years, a maltose neopentyl glycol (MNG) amphiphile, known as lauryl maltose neopentyl glycol (LMNG), has facilitated crystal structure determinations of approximately 30 membrane proteins including various GPCRs. This noel agent contains two alkyl chains with the same chain length. In this presentation, we introduce LMNG variants with different alkyl chain length. This structural modification results in length variation in the hydrophobic groups and molecular geometry of detergent molecules, thus affecting detergent efficacy for membrane protein solubilization and stabilization.

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