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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cell Encapsulation: Cytoprotection of Living Cells against External Stresses

등록일
2018년 2월 23일 14시 52분 07초
접수번호
6222
발표코드
BIO.O-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 00분
발표형식
구두발표
발표분야
Life Chemistry - Oral Presentation in Chemistry of Life
저자 및
공동저자
BEOM JIN KIM, INSUNG CHOI*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
Cell encapsulation, forming cell-in-shell structures, provides a chemical tool for the isolation and protection of living cells from harmful, and often lethal, external environments. The nanometric shell provides exogenous properties that are neither innate nor naturally achievable, and enhanced tolerance in vitro against lethal factors in real-life settings. Herein, we introduce simple strategies for forming cell-in-shell structures. First, we developed a simple polydopamine coating for obtaining cytoprotective capability of the alginate microbead that encapsulated Saccharomyces cerevisiae. The resulting alginate/polydopamine core/shell microbeads was mechanically tough, prevented gel swelling and cell leakage, and increased resistance against enzymatic attack and UV-C irradiation. Next, we reported the interfacial supramolecular self-assembly and shell formation of ferric ions (FeIII) and tannic acid (TA) for cell encapsulation, where FeIII and TA come into contact each other and self-assemble across the interface of two immiscible phases. The interfacial shell formation developed is simple, fast, and cytocompatible. Its versatility is demonstrated with various biphasic systems: hollow microcapsules, encasing microbial or mammalian cells that are generated at the water-oil interface; a cytoprotective FeIII-TA shell that forms on the surface of the alginate microbead, which then entraps probiotic Lactobacillus acidophilus; and a pericellular FeIII-TA shell that forms on individual Saccharomyces cerevisiae. These simple strategies for cell encapsulation will advance chemical manipulability of living cells.

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