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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Investigation of quantitative performance of paper cone spray ionization (PCSI) mass spectrometry (MS)

2018년 2월 12일 14시 27분 37초
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목 10시 : 35분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
TaeMin Park, Sangwon Cha*
Department of Chemistry, Hankuk University of Foreign Studies, Korea
Paper cone spray ionization (PCSI), an extractive ambient ionization method for mass spectrometry (MS), is a modified version of paper spray ionization (PSI) for raw solid material analysis. The major modification from conventional PSI was the geometry of the paper base: PCSI uses a triangular-pyramidal-shaped paper tip instead of a planar triangular-shaped one. This three-dimensional paper cone serves as a sample container, an in situ liquid-solid extraction chamber, an analyte transport channel, as well as an electrospray tip. Unlike conventional PSI MS, a weighing paper with relatively low permeability was found to be more suitable for PCSI MS than other papers. In contrast to the previous PCSI MS studies that mainly focused on qualitative, fingerprinting analysis, this study aims to evaluate quantitative performance of PCSI MS. In order to achieve this, we prepared a model pharmaceutical powder consisting of avicel, microcrystalline cellulose that is the most widely used direct-compression tablet filler, and acetaminophen. We performed wicking-mode PCSI MS analysis with model powders with various contents of acetaminophen and successfully obtained solid-liquid extraction patterns and intensity information of acetaminophen ions. From the results, we found that PCSI MS showed a good linearity although its range was somewhat limited.